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August 03, 2009
Abstract of Publication: Phase I/II Trial of AEG35156 X-Linked Inhibitor of Apoptosis Protein Antisense Oligonucleotide Combined With Idarubicin and Cytarabine in Patients With Relapsed or Primary Refractory Acute Myeloid Leukemia. |
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February 01, 2009
Abstract of Publication: Cytoprotective Effects of IAPs Revealed by a Small Molecule Antagonist |
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June 20, 2008
Abstract of Publication: cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination |
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December 01, 2007
Abstract of Publication: X-linked inhibitor of apoptosis regulates T cell effector function |
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September 01, 2006
Abstract of Publication: Preclinical Characterization of AEG35156/GEM640, a Second-Generation Antisense Oligonucleotide Targeting X-Linked Inhibitor of Apoptosis |
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April 30, 2006
Poster presented at Keystone Structure Based Discovery Meeting in Whistler BC: XIAP BIR Binding Small Molecule Inhibitors Lead to Highly Active Pro-Apoptotic Compounds in Cancer Cell Lines |
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March 31, 2006
Poster presented at the 231st ACS National Meeting in Atlanta: Novel BIR Binding Ligands as XIAP Antagonists: High Potency Anti-Cancer Agents |
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February 13, 2006
Abstract of publication: AEG3482 is an antiapoptotic compound that inhibits Jun kinase activity and cell death through induced expression of heat shock protein 70 |
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November 30, 2005
Poster: A Phase I Trial of AEG35156 administered as a 7-day continuous intravenous infusion in patients with advanced tumours |
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November 30, 2005
Poster: Antitumor activity of AEG35156 correlates with suppression of XIAP in human cancer models |
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November 30, 2005
Abstract of publication: Application of XIAP Antisense to Cancer and Other Proliferative Disorders: Development of AEG35156/ GEM(R)640. |
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October 31, 2005
Poster: Novel BIR Binding Ligands as XIAP Antagonists |
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February 14, 2005
Abstract of publication: Validation of pharmacodynamic assays to evaluate the clinical efficacy of an antisense compound (AEG 35156) targeted to the X-linked inhibitor of apoptosis protein XIAP |
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March 31, 2004
Poster: AEG3482 Attenuates Paclitaxel- and Cisplatin-Induced Peripheral Neuropathy |
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March 31, 2004
AEG35156 demonstrates significant antitumor activity in multiple human cancer xenograft models |
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